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Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.
Kalappa BI, Soh H, Duignan KM, Furuya T, Edwards S, Tzingounis AV, Tzounopoulos T. Kalappa BI, et al. J Neurosci. 2015 Jun 10;35(23):8829-42. doi: 10.1523/JNEUROSCI.5176-14.2015. J Neurosci. 2015. PMID: 26063916 Free PMC article.
Moreover, unlike retigabine, SF0034 did not shift the voltage dependence of either KCNQ4 or KCNQ5 homomeric channels. ...Behavioral studies demonstrated that SF0034 was a more potent and less toxic anticonvulsant than retigabine in rodents. Furthermore, SF0034 preve …
Moreover, unlike retigabine, SF0034 did not shift the voltage dependence of either KCNQ4 or KCNQ5 homomeric channels. ...Behavioral s …
Potassium ion channel openers, Maxipost and Retigabine, protect against peripheral salicylate ototoxicity in rats.
Sheppard AM, Chen GD, Salvi R. Sheppard AM, et al. Hear Res. 2015 Sep;327:1-8. doi: 10.1016/j.heares.2015.04.007. Epub 2015 May 1. Hear Res. 2015. PMID: 25937133
Sodium Salicylate (SS) reliably induces a sensorineural hearing loss and tinnitus when administered in high doses. Recent animal modeled studies indicate that potassium channel openers such as Maxipost and Retigabine (RTG) can block SS- or noise-induced tinnitus …
Sodium Salicylate (SS) reliably induces a sensorineural hearing loss and tinnitus when administered in high doses. Recent animal mode …
Pharmacodynamics of potassium channel openers in cultured neuronal networks.
Wu C, V Gopal K, Lukas TJ, Gross GW, Moore EJ. Wu C, et al. Eur J Pharmacol. 2014 Jun 5;732:68-75. doi: 10.1016/j.ejphar.2014.03.017. Epub 2014 Mar 25. Eur J Pharmacol. 2014. PMID: 24681057 Free article.
Pentylenetetrazol was used to create hyperactivity states in the neuronal networks as a first approximation for mimicking tinnitus or tinnitus-like activity. We then compared the pharmacodynamics of the four channel activators, retigabine and flupirtine (volt …
Pentylenetetrazol was used to create hyperactivity states in the neuronal networks as a first approximation for mimicking tinnitus or …
Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators.
Kumar M, Reed N, Liu R, Aizenman E, Wipf P, Tzounopoulos T. Kumar M, et al. Mol Pharmacol. 2016 Jun;89(6):667-77. doi: 10.1124/mol.115.103200. Epub 2016 Mar 22. Mol Pharmacol. 2016. PMID: 27005699
KQT-like subfamily (KCNQ) channels are voltage-gated, noninactivating potassium ion channels, and their down-regulation has been implicated in several hyperexcitability-related disorders, including epilepsy, neuropathic pain, and tinnitus. Activators of these channels redu …
KQT-like subfamily (KCNQ) channels are voltage-gated, noninactivating potassium ion channels, and their down-regulation has been implicated …