Rala Ras-like protein A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ralaprovided by FlyBase
Official Full Name: Ras-like protein Aprovided by FlyBase
Primary source: FLYBASE:FBgn0015286
Locus tag: Dmel_CG2849
See related: AllianceGenome:FB:FBgn0015286
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 24639550; anon-EST:fe1H4; CG2849; D-RalA; Dm RalA; Dmel\CG2849; dRal; Dral; DRal; Drala; DralA; DRala; l(1)G0174; l(1)G0373; l(1)G0501; P48555; ral; Ral; Ral-a; rala; ralA; RalA; RALA
Summary: Enables GTPase activity and PDZ domain binding activity. Involved in several processes, including R3/R4 cell fate commitment; border follicle cell migration; and negative regulation of JNK cascade. Located in plasma membrane. Is expressed in several structures, including egg chamber; embryonic/larval central nervous system; embryonic/larval digestive system; imaginal disc; and outer photoreceptor cell. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to several human genes including RALA (RAS like proto-oncogene A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 3E5-3E6; 1-4 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (3704610..3719635, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (3598643..3613668, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.
Title: RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.
Ral function in muscle is required for flight maintenance in Drosophila.
Title: Ral function in muscle is required for flight maintenance in Drosophila.
RalA GTPase is regulating wrapping glia and nerve bundle development via the exocyst complex, and required for normal locomotion.
Title: Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex.
The RalA was required within intestinal stem cells (ISCs) for efficient regeneration downstream of Wnt signaling.
Title: RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes.
data indicate that Ral and the exocyst regulate autophagy in a context-dependent manner, and that in dying salivary glands, Ral mediates autophagy, at least in part, by regulation of Notch.
Title: Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner.
These studies identify a pathway, which stretches from Rab8 to RalA and the exocyst complex, that mediates rapid furrow formation in early Drosophila embryos.
Title: A rapid, membrane-dependent pathway directs furrow formation through RalA in the early Drosophila embryo.
Constitutively active Ral expressed in muscle causes the exocyst to be concentrated in the region surrounding synaptic boutons and consequently enlarges the membrane folds of the postsynaptic plasma membrane.
Title: Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst.
Ral inhibits ligandindependent Notch activation, all known forms of which take place in endosomes.
Title: Ral inhibits ligand-independent Notch signaling in Drosophila.
the Rap1-Rgl-Ral signaling network is a novel mechanism that cooperates with other intrinsic polarity cues to modulate asymmetric neuroblast division
Title: The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation.
prevention of ligand-independent Notch activation is not simply a constitutive process, but is a target for regulation by Ral during cell fate specification and pattern formation.
Title: Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R3/R4 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of innate immune response	HMP more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ras-like protein A

Names: CG2849-PA; CG2849-PB; CG2849-PC; Rala-PA; Rala-PB; Rala-PC; Ras-related protein; anon-fast-evolving-1H4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

3704610..3719635 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080324.4 → NP_525063.1 Ras-like protein A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525063.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48555, Q540X1, Q9W4Q6

Related

FBpp0070559

Conserved Domains (1) summary

cd04139
Location:12 → 174

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
NM_166985.3 → NP_726881.1 Ras-like protein A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726881.1

Status: REVIEWED

UniProtKB/TrEMBL

Q962I2

Related

FBpp0070557

Conserved Domains (1) summary

cd04139
Location:12 → 174

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
NM_166986.3 → NP_726882.1 Ras-like protein A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726882.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48555, Q540X1, Q9W4Q6

Related

FBpp0070558

Conserved Domains (1) summary

cd04139
Location:12 → 174

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB