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    CG42399 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33176, updated on 27-Mar-2024

    Summary

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    Official Symbol
    CG42399provided by FlyBase
    Primary source
    FLYBASE:FBgn0259818
    Locus tag
    Dmel_CG42399
    See related
    AllianceGenome:FB:FBgn0259818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11620; CG4648; Dmel\CG42399
    Old locus tag
    Dmel_CG11620; Dmel_CG4648
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle assembly. Predicted to be active in cilium and microtubule cytoskeleton. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to several human genes including TOGARAM1 (TOG array regulator of axonemal microtubules 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    21B3-21B3; 2-0.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (144231..153300, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (144231..153300, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 15 kDa subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Pseudouridine synthase 10 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNAi experiments in D. melanogaster: solutions to the overlooked problem of off-targets shared by independent dsRNAs. Seinen E, et al. PLoS One, 2010 Oct 1. PMID 20957038, Free PMC Article
    2. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
    3. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
    4. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848
    5. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42399-PB
    CG42399-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      144231..153300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272872.1 → NP_001259801.1  uncharacterized protein Dmel_CG42399, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJI4, M9PAY4
      Conserved Domains (1) summary
      pfam12348
      Location:1431 → 1625
      CLASP_N; CLASP N terminal

    2. NM_134654.5 → NP_608498.3  uncharacterized protein Dmel_CG42399, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608498.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJI4, Q9VPK5
      Conserved Domains (1) summary
      pfam12348
      Location:1433 → 1627
      CLASP_N; CLASP N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PAY4 M9PAY4
    Q8MZ39 Q8MZ39
    Q9VPK5 Q9VPK5

    Gene LinkOut

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